NREMT Paramedic Practice

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What symptom is associated with an anticholinergic overdose?

Bradycardia
Dry/flushed skin
SLUDGE
Dizziness

The correct answer is: Dry/flushed skin

In the context of an anticholinergic overdose, dry or flushed skin is a hallmark symptom due to the inhibition of acetylcholine, which is responsible for many of the body’s involuntary functions, including the regulation of sweat glands. When acetylcholine activity is reduced, the body experiences decreased sweating, leading to dry skin. Additionally, the flushed appearance results from vasodilation, which is another consequence of anticholinergic action, making this symptom particularly indicative of such an overdose. The symptoms associated with anticholinergic toxicity usually include a range of other effects, but they do not typically center around the activation of sweat glands or muscarinic receptor stimulation, which would be seen in other conditions. This helps in differentiating anticholinergic overdose from other types of overdose or medical emergencies.